一、教育、工作经历：

2024年01月-至今，东莞理工学院生命健康技术学院，特聘副研究员，学科骨干，教师

2020年07月-2023年06月, 深圳大学, 生物医学工程，博士后

2015年09月-2020年06月, 四川大学, 有机化学，博士（硕博连读）

2011年09月-2015年06月, 四川大学, 应用化学，学士

二、研究领域：

1. 新颖LNPs的设计和构建

利用化学的手段，针对mRNA递送过程中可能出现的障碍，设计合成新型的LNPs；利用生物学的研究方法，系统地考察mRNA-LNPs的递送效率和体内治疗效果。运载体的生物性质、构效关系将作为重要信息反馈用以指导载体化学结构的进一步改造合成，从而实现高效的mRNA治疗。

2. 肿瘤精准治疗/诊疗一体化

利用治疗性小分子药物或生物药物靶向肿瘤特定的信号通路，抑制肿瘤生长，实现肿瘤的精准治疗；应用免疫学原理和方法，激发和增强机体抗肿瘤免疫应答，杀伤肿瘤细胞，抑制肿瘤生长；利用肿瘤治疗过程中引发的特定分子信号的变化，结合成像技术如荧光成像、光声成像等，实现肿瘤的精准诊疗。

三、主要业绩：

主持国家自然科学基金青年项目1项，作为核心成员参与多项国家科学基金面上项目；先后在Chem. Soc. Rev.（中科院一区Top，IF: 39.0）、Angew Chem. Int. Ed.（中科院一区Top IF: 16.9）、Adv. Compos. Hybrid Mater. （中科院一区Top，IF: 23.2）等国际权威期刊发表SCI论文20篇，以第一作者/通讯作者的身份发表了10篇研究性论文，授权专利1项。

四、代表性研究成果：

（一）论文/论著

1. Ya-Ping Xiao, Jiayingzi Wu, Peng-Hang Chen, Shan Lei, Jing Lin*, Xin Zhou* and Peng Huang*. Biocatalytic cascade reactions for management of diseases. Chem. Soc. Rev. 2025, 54 (7), 3247.

2. Meimei Wang^†, Yaping Xiao^†, Jie Miao, Xin Zhang, Meng Liu, Longchao Zhu, Hongxin Liu, Xiaoyan Shen, Jihui Wang, Biao Xie*, Di Wang*, Oxidative Stress and Inflammation: Dual Drivers of Tumorigenesis and Therapeutic Opportunities, Antioxidants, 2025, 14, 735.

3. Biao Xie^†, Meimei Wang^†, Yaping Xiao, Xin Zhang, Meng Liu, Jie Miao, Yunfei Mo, Hongxin Liu, Jihui Wang, Fengguo Xu*, Di Wang*. Tryptophan metabolic gatekeeping in epithelial repair: GPR35-KLF5 circuitry decodes mucosal damage signals for repair programming. Cell Death & Disease, 2026, 17(1):25.

4. Dan Zhao, Ya-Ping Xiao*, Mengyang Li*, Liang Luo*. Recent advances of Cyanine dyes in tumor theranostics: Molecular modification, delivery strategies, and synergistic mechanisms. RSC Advances 已接收

5. Ya-Ping Xiao^†, Peng-Hang Chen^†, Shan Lei, Fang Bai, Lian-Hua Fu, Jing Lin, Peng Huang*. Biocatalytic depletion of tumorigenic energy sources driven by cascade reactions for efficient antitumor therapy. Angew. Chem. Int. Ed. 2022, 61, e202204584.

6. Ya-Ping Xiao, Ji Zhang**, Yan-Hong Liu, Zheng Huang, Xiao-Qi Yu*. Fluorinated polymer emulsion systems: Construction and application in delivering genes and proteins. Eur. J Med. Chem. 2020, 207, 112799.

7. Ya-Ping Xiao, Ji Zhang*, Yan-Hong Liu, Ju-Hui Zhang, Qing-Ying Yu, Zheng Huang, Xiao-Qi Yu*. Low molecular weight PEI-based fluorinated polymers for efficient gene delivery. Eur. J. Med. Chem. 2019, 162, 602-611.

8. Ya-Ping Xiao, Ji Zhang*, Yan-Hong Liu, Zheng Huang, Yu Guo, Xiao-Qi Yu*. Bioinspired pyrimidine-contained cationic polymers as effective nano-carriers for DNA and protein delivery. J. Mater. Chem. B 2020, 8, 2275-2285.

9. Ya-Ping Xiao, Ji Zhang*, Yan-Hong Liu, Zheng Huang, Bing Wang, Yi-Mei Zhang, Xiao-Qi Yu*. Cross-linked polymers with fluorinated bridges for efficient gene delivery. J. Mater. Chem. B 2017, 5, 8542-8553.

10. Ya-Ping Xiao, Ji Zhang*, Yan-Hong Liu, Xiao-Chuan Chen, Qing-Ying Yu, Chao-Ran Luan, Ju-Hui Zhang, Xi Wei, Xiao-Qi Yu*. Ring-opening polymerization of diepoxides as an alternative method to overcome PEG dilemma in gene delivery. Polymer 2018, 134, 53-62.

11. Ya-Ping Xiao^†, Peng-Hang Chen^†, Qiang Liu, Shan Lei, Fang Bai, Jing Lin, Peng Huang*. An ATP-unlocked target system breaking pH and H₂O₂ limitations for tumor-specific mutually reinforcing therapy. (Submission to Angew. Chem. Int. Ed.)

12. Ya-Ping Xiao^†, Qiang Liu^†, Shan Lei, Jing Lin, Peng Huang*. Enzymes-engineering biocatalytic cascade nanoreactors for efficient metabolism-based antitumor therapy. (Ready for Paper)