一、教育、工作经历：

2024年1月 – 至今            东莞理工学院 生命健康技术学院 学科领军，教授，博士后合作导师

2015年7月 – 2024年1月  中北大学 信息与通信工程学院 教授，博士生导师

2013年7月－2015年6月  美国肯塔基大学 生物医学工程系，研究员(Scientist I)

2011年7月－2013年6月  美国心脏协会/肯塔基大学，博士后研究员(Postdoctoral Fellow)

2008年7月－2011年6年  美国肯塔基大学，生物医学工程中心，博士后学者(Postdoctoral Scholar)

2004年9月－2008年7月  清华大学，生物医学工程专业，工学博士

2001年9月－2004年7月  吉林大学 生物医学工程专业，工学硕士

2000年6月－2004年8月  吉林大学，数学科学学院，教师

1999年7月－2000年6月  长春科技大学，应用理学院，教师

1995年9月－1999年7月  吉林大学，应用数学专业，理学学士

二、研究领域：

开发近红外漫射光谱(near-infrared diffuse optical spectroscopy-NIRS)以及相关光谱与成像(diffuse correlation spectroscopy/ tomography, DCS/DCT)技术探测生物组织的血流动力学信息(包括血流、血氧和氧代谢)。NIRS是根据光子在生物组织内输运过程中吸收和散射的特性来测量血氧含量的传统方法；DCS/DCT是根据光场时间自相关函数在动态散射体扩散原理测量血流的新技术。本团队长期从事NIRS和 DCS/DCT技术的开发，并将这些技术成功地应用于临床。具体包括：

1. 光学仪器设计；包括优化激光器、光子探测器和数字相关器的配置及软件控制，实现快速和高效的光子数据获取。

2. 光场的物理建模及信息计算；通过分析生物组织内运动的红细胞对光场相关性的影响，建立动态光散射的数学模型和血流信息计算方法。

3. 医学计算成像及信号和图像处理；系统地考察光学信号的噪声来源以及对血流测量的影响，并在此基础上开发与生理状态相关联的DCS血流测量方式和去噪算法；以及开发结合形态学影像的精确DCT血流计算成像方法和图像处理方法。

4. 漫射光技术的临床应用；将开发的NIRS和DCS/DCT技术应用于脑、骨骼肌及肿瘤等组织和器官，进行多种的疾病早期诊断和治疗评估。

三、主要业绩：

近年来的主要工作是：发展近红外漫射光技术来无创检测生物组织的血流、血氧和代谢，并应用于临床，进行多种疾病早期诊断和治疗评估。 曾经主持美国心脏协会（AHA）的基金一项，参与美国国立卫生院（NIH）等机构的基金三项；作为负责人和首席科学家，2016年和2023年先后承担国家重点研发计划“数字诊疗装备研发”和“战略性科技创新合作”两个重点专项，以及国家自然科学基金、山西省重点研发计划、山西省基础研究计划、企业横向等科研项目；发表SCI论文50余篇，SCI引用1300余次。曾任IEEE等3个国际会议的委员会主席或执行委员。中国医疗保健国际交流促进会重症医学专业委员会常委、微电子与光电子材料与器件专家委员会副主任委员、中国光学学会光电技术专业委员会委员，中国仪器仪表学会光机电技术与系统集成分会理事，中国光学学会生物医学光子学专业委员会委员，中国体视学学会智能成像专业委员会委员；目前担任5种国际期刊的编委/客座编辑和20余种国际期刊的审稿人。2017年聘任“山西特聘专家”，2018年入选“三晋英才”人才计划和中共山西省委联系的高级专家。

四、讲授课程：

1. 本科生：《生物医学工程专业英语》、《生物医学工程创新教育实践》、《复变函数》、《数学物理方程》、《概率统计》、《数字信号处理》

2. 研究生：《科技外语写作》、《计算成像理论和方法》（留学生，全英文）、《数值分析》（留学生，全英文）

五、代表性研究成果：

（一）SCI期刊论文 （* 通讯作者）

1. W Li , Z Zhang , Z Li , Z Gui , Y Shang^* . Correlation and asynchronization of electroencephalogram and cerebral blood flow in active and passive stimulations. Journal of Neural Engineering 20(6), 066007,2023.

2. X Zhao , G Hao, Y Shang^* , J Han^*. Three-Dimensional Gradient Metamaterial Devices Coupled with Phononic Crystals for Acoustic Enhancement Sensing. Crystals. 13(8):1191,2023.

3. S. Feng, Z. Gui,  X. Zhang , Y. Shang^*, "Collimating micro-lens fiber array for noncontact near-infrared diffuse correlation tomography", Biomedical Optics Express, 12(3), 1467-1481,2021.

4. J. Bai,  Q. Zhu, Y. Liu, Y. Zhou,T. Shi, Z. Gui, Y. Shang^*, " PV-MBLL algorithm for extraction of absolute tissue oxygenation information by diffuse optical spectroscopy". Computer methods and programs in biomedicine, 193, 105456, 2020.

5. X. Zhang, L. Zhai,  J. Wang, G. Lou, Y. Shang, Z. Gui, ART-TV algorithm for diffuse correlation tomography blood flow imaging. IEEE Access, 8, 136819-136827,2020.

6. A. A. Bahrani, W. Kong, Y. Shang,C. Huang ,C. D.  Smith, D. K. Powell, &  G.  Yu, Diffuse optical assessment of cerebral‐autoregulation in older adults stratified by cerebrovascular risk. Journal of Biophotonics, 13(10), e202000073,2020.

7. J. Zuo, X. Zhang, J. Lu, Z. Gui, Y. Shang^*,"Impact of Reconstruction Algorithms on Diffuse Correlation Tomography Blood Flow Imaging", IEEE Access, 8, 31882- 31891, 2020.

8. H. Ling, Z. Gui, H. Hao, Y. Shang^*," Enhancement of diffuse correlation spectroscopy tissue blood flow measurement by acoustic radiation force ", Biomedical Optics Express 11 (1), 301-315,2020.

9. Y. Zhu, Z. Gui, B. Xue, Y. Shang^*,"Experimental Validation of Microvasculature Blood Flow Modeling by Diffuse Correlation Spectroscopy", IEEE Access,8, 15945-15951, 2020.

10. L. Hou, Y. Liu, L. Qian, Y. Zheng, J. Gao, W. Cao, Y. Shang^*, "Portable near-infrared technologies and devices for noninvasive assessment of tissue hemodynamics"，Journal of Healthcare Engineering , 2019,3750495,2019.

11. P. Zhang, Z. Gui, G. Guo, Y. Shang^*. Approaches to denoise the diffuse optical signals for tissue blood flow measurement, Biomedical Optics Express, 9(12), 6170-6185,2018.

12. Y. Shang^*, "Advances in Reconstructed Algorithms for Diffuse Correlation Spectroscopy and Tomography", Lecture Notes in Electrical Engineering, 506,15-28,2018.

13. J. Li, W. Han, Y. Li,Y. Chen, Y. Shang, Y Chen, Z. Gui, "Inverse problem based on the fast alternating direction method of multipliers algorithm in multiangle total internal reflection fluorescence microscopy," Applied Optics, 57(33), 9828-34, 2018.

14. L. Jia, Q. Zhang, Y. Shang, Y. Wang, Y. Liu ; N. Wang, Z. Gui, G.Yang, "Denoising for Low-Dose CT Image by Discriminative Weighted Nuclear Norm Minimization," IEEE Access,6, 46179-93,2018.

15. N. Wang, Y. Shang, Y. Chen, M. Yang, Q. Zhang, Y. Liu, Z. Gui, “A Hybrid Model for Image Denoising Combining Modified Isotropic Diffusion Model and Modified Perona-Malik Model”, IEEE Access,6, 33568-82,2018.

16. T. Li, P. Wang,L. Qiu, X. Fang,and Y. Shang, “Optimize Illumination Parameter of Low-Level Laser Therapy for Hemorrhagic Stroke by Monte Carlo Simulation on Visible Human Dataset”, IEEE Photonics Journal,10(3), 6100409 ,2018.

17. X. Zhang, Z. Gui, Z. Qiao, Y.Liu, and Y. Shang*, Nth-order linear algorithm for diffuse correlation tomography, Biomedical Optics Express, 9(5), 2365-2382,2018.

18. J. Guo, Z. Gui, H. Hou, Y. Shang^*, “Flexible positioning of source-detector arrays in 3D visualization platform for Monte Carlo simulation of light propagation,” IEEE Access,5,26673-80,2017.

19. S. Luo, X. Shen, X. Bai, J. Bai, J. Han,and Y. Shang^*, “Validation of material algorithms for femur remodelling Using Medical Image Data”, Applied Bionics and Biomechanics,2017, 5932545, 2017.

20. Y. Shang, T. Li, G. Yu, "Clinical applications of near-infrared diffuse correlation spectroscopy and tomography for tissue blood flow monitoring and imaging," Physiological Measurement, 1361-6579, 2017.

21. C. Huang, D. Irwin, M. Zhao, Y. Shang, N. Agochukwu, L. Wong, G. Yu, "Noncontact 3-dimensional Speckle Contrast Diffuse Correlation Tomography of Tissue Blood Flow Distribution", IEEE Transactions on Medical Imaging,2017.

22. L. Dong, M. Kudrimoti, D. Irwin, L. Chen, S. Kumar, Y. Shang, C. Huang, E. Johnson, S. Stevens, B. Shelton, G. Yu, “Diffuse optical measurements of head and neck tumor hemodynamics for early prediction of chemo-radiation therapy outcomes,” Journal of Biomedical Optics, 21(8), 085004,2016.

23. B. Henry, M. Zhao, Y. Shang, et al. “Hybrid diffuse optical techniques for continuous hemodynamic measurement in gastrocnemius during plantar flexion exercise” Journal of Biomedical Optics 20(12), 125006,2015.

24. C. Huang, D. Irwin, Y. Lin, Y. Shang, L. He, W. Kong, J. Luo, G. Yu, “Speckle contrast diffuse correlation tomography of complex turbid medium flow,” Medical Physics, 42(7), 4000,2015.

25. C. Huang, J. P. Radabaugh, R. K. Aouad, Y. Lin, T. J. Gal, A. B. Patel, J. Valentino, Y. Shang, G. Yu, “Noncontact Diffuse Optical Assessment of Blood Flow Changes in Head and Neck Free Tissue Transfer Flaps,” Journal of Biomedical Optics, 20(7), 075008,2015.

26. Y. Shang and G. Yu, “A Nth-order linear algorithm for extracting diffuse correlation spectroscopy blood flow indices in heterogeneous tissues,” Applied Physics Letters, 105, 133702,2014.

27. Y. Shang, T. Li, L. Chen, Y. Lin, M. Toborek, G. Yu, “Extraction of diffuse correlation spectroscopy flow index by integration of Nth-order linear model with Monte Carlo simulation,” Applied Physics Letters, 104, 193703,2014.

28. Y. Hou*, Y. Shang*, R. Cheng, Y. Zhao, Y. Qin, R. Kryscio, A. Rayapati, D. Hayes Jr, G. Yu, “Obstructive sleep apnea–hypopnea results in significant variations in cerebral hemodynamics detected by diffuse optical spectroscopies,” Physiological Measurement, 35, 2135,2014. *Contributed equally

29. R. Cheng, Y. Shang, S. Wang, J. M. Evans, A. Rayapati, D.C. Randall, G. Yu, “Near-infrared diffuse optical monitoring of cerebral blood flow and oxygenation for the prediction of vasovagal syncope”, Journal of Biomedical Optics 19(1), 017001,2014.

30. Y. Lin, C. Huang, D. Irwin, L. He, Y. Shang, G. Yu, “Three-dimensional flow contrast imaging of deep tissue using noncontact diffuse correlation tomography,” Applied Physics Letters, 104(12), 121103,2014.

31. Y. Shang, Y. Lin, B.A. Henry, R. Cheng, C. Huang, L. Chen, B.J. Shelton, K.R. Swartz, S.S. Salles, G. Yu, “Noninvasive Evaluation of Electrical Stimulation Impacts on Muscle Hemodynamics via Integrating Diffuse Optical Spectroscopies with Muscle Stimulator,” Journal of Biomedical Optics, 18(10), 105002,2013.

32. L. He, Y. Lin, Y. Shang, B. Shelton, G. Yu, “Using optical fibers with different modes to improve the signal-to-noise ratio (SNR) of diffuse correlation spectroscopy (DCS) flow-oximeter measurements,” Journal of Biomedical Optics, 18(3), 037001,2013.

33. T. Li, Y. Lin, Y. Shang, L. He, C. Huang, M. Szabunio, G. Yu, “Simultaneous measurement of deep tissue blood flow and oxygenation using noncontact diffuse correlation spectroscopy flow-oximeter,” Scientific Reports, 3, 1358,2013.

34. L. Dong, L. He, Y. Lin, Y. Shang, G. Yu, “Simultaneously extracting multiple parameters via fitting one single autocorrelation function curve in diffuse correlation spectroscopy”, IEEE Transactions on Biomedical Engineering, 60(2), 361-368, 2013.

35. R. Srikuea, T. B. Symons, D. E. Long, J. Lee, Y. Shang, P. J. Chomentowski, G. Yu, L. J. Crofford, C. A. Peterson, “Association of fibromyalgia with altered skeletal muscle characteristics which may contribute to postexertional fatigue in postmenopausal women,” Arthritis & Rheumatism, 65(2),519-28,2013.

36. R. C. Mesquita, M. Putt, M. Chandra, G. Yu, X. Xing, S. W. Han, G. Lech, Y. Shang, T. Durduran, C. Zhou, A. G. Yodh, E. R. Mohler, III, “Diffuse optical characterization of an exercising patient group with peripheral artery disease,” Journal of Biomedical Optics, 18(5), 057007,2013.

37. Y. Shang, K. Gurley, G. Yu, “Diffuse Correlation Spectroscopy (DCS) for Assessment of Tissue Blood Flow in Skeletal Muscle: Recent Progress,” Anatomy & Physiology, 3(2), 1000128, 2013.

38. Y. Shang, K. Gurley, B. Symons, D. Long, R. Srikuea, L. J. Crofford, C. A. Peterson, G. Yu, “Noninvasive optical characterization of muscle blood flow, oxygenation, and metabolism in women with fibromyalgia”, Arthritis Research & Therapy, 14, R236,2012.

39. R. Cheng, Y. Shang, D. Hayes, S.P. Saha, G.Yu, “Noninvasive optical evaluation of spontaneous low frequency oscillations in cerebral hemodynamics,” NeuroImage, 62(3), 1445-1454 ,2012.

40. K. Gurley, Y. Shang, and G. Yu, “Noninvasive optical quantification of absolute blood flow, blood oxygenation, and oxygen consumption rate in exercising skeletal muscle,” Journal of Biomedical Optics, 17(7), 075010 ,2012.

41. Y. Lin, L. He, Y. Shang, G. Yu, “Noncontact diffuse correlation spectroscopy for noninvasive deep tissue blood flow measurement,” Journal of Biomedical Optics, 17, 010502 ,2012.

42. L. Chen, Y. Shang, E. Sipos, K. E. Saatman, G. Yu, M Toborek, “Novel experimental model for repeated forebrain ischemia-reperfusion” Journal of Experimental Stroke and Translational Medicine, 5(1), 1-10, 2012.

43. N. Munk, B. Symons, Y. Shang, R. Cheng, and G. Yu, "Noninvasively measuring the hemodynamic effects of massage on skeletal muscle: a novel hybrid near-Infrared diffuse optical instrument," Journal of Bodywork and Movement Therapies, 16(1), 22-28, 2012).

44. L. Dong, M. Kudrimoti, R. Cheng, Y. Shang, E. L. Johnson, S. D. Stevens, B. J. Shelton, and G. Yu, “Noninvasive diffuse optical monitoring of head and neck tumor blood flow and oxygenation during radiation delivery,” Biomedical Optics Express, 3(2), 259-272,2012.

45. Y. Shang, L. Chen, M. Toborek, and G. Yu, "Diffuse optical monitoring of repeated cerebral ischemia in mice," Optics Express, 19(21), 20301-20315, 2011.

46. Y. Shang, R. Cheng, L. Dong, S.J. Ryan, S.P. Saha, and G. Yu, "Cerebral monitoring during carotid endarterectomy using near-infrared diffuse optical spectroscopies and electroencephalogram", Physics in Medicine and Biology 56(10), 3015-32, 2011.

47. G. Yu, Y. Shang, Y. Zhao, R. Cheng, L. Dong, and S.P. Saha, "Intraoperative evaluation of revascularization effect on ischemic muscle hemodynamics using near-infrared diffuse optical spectroscopies," Journal of Biomedical Optics 16(2), 027004,2011.

48. D. Irwin, L. Dong, Y. Shang, R. Cheng, M. Kudrimoti, S.D. Stevens, and  G. Yu, "Influences of tissue absorption and scattering on diffuse correlation spectroscopy blood flow measurements," Biomedical Optics Express 2, 1969-1985, 2011.

49. Y. Shang, T. B. Symons, T. Durduran, A. G. Yodh, and G. Yu, "Effects of muscle fiber motion on diffuse correlation spectroscopy blood flow measurements during exercise," Biomedical Optics Express 1, 500-511, 2010.

50. Y. Shang, Y. Zhao, R. Cheng, L. Dong, D. Irwin, and G. Yu, "Portable optical tissue flow oximeter based on diffuse correlation spectroscopy," Optics Letters 34, 3556-3558,2009.

51. Y. Shang, J. Bai and L. Peng, "The effects of the spatial influence function on orthotropic femur remodeling," Proceedings of the Institution of Mechanical Engineers Part H - Journal of Engineering in Medicine 222 (5), 601-609,2008.

52. Y. Shang, J. Bai, L. Peng and J. Lau, "Comparison of methods for determining orthotropic axes in 3D femur remodeling," Progress in Natural Science 17 (12), 1405-1411, 2007.

（二）SCI期刊编委评述论文:

1. Y. Shang, T. Li and C. Huang, "Editorial: Functional near-infrared diffuse optical spectroscopy (fNIRS) to explore mental health", Front. Psychiatry 13:1021622. 2022.

2. T. Li, Y. Shang, W. Ge, "Optical Technologies for Healthcare and Wellness Applications", Journal of Healthcare Engineering , 1321348 ,2019.

3. Y. Shang, Z. Qian, R.C. Mesquita, M. Dehaes, “Recent Advances in Optical Spectroscopic and Imaging Methods for Medicine and Biology,” Journal of Spectroscopy, 4095790, 2016.

（三）主持的科研项目

1.  “Development of diffuse optical spectroscopies for monitoring cerebral blood flow and oxygenation in mouse stroke model”

   美国心脏协会(AHA)博士后基金#11POST7360020 2011/7/1-2013/6/30

   经费： $88,000

2. “结合形态学影像的近红外漫射光血流断层成像系统”

   国家重点研发计划（科技部）2016YFC0101600 2016/7/1-2018/12/31

   经费：￥1,574,200

3. “结合医学影像先验信息的近红外漫射光血流血氧测量技术研究”

   国家自然科学基金面上项目 61771433    2018/1/1-2018/12/31

   经费：￥188,500

4. “医学成像与信息处理”

   山西省高等学校中青年拔尖创新人才支持计划    2018/08/01-2020/12/31

   经费：￥200,000

5. “脑部血流动力学精确测量的近红外漫射光技术研究”

   山西省重点研发计划项目201903D121149    2019/07/01-2021/12/31

   经费：￥200,000

6. “基于漫射光自相关技术的动态血流断层成像研究”

   山西省基础研究计划项目 202203021221097 2023/01/01-2025/12/31

   经费：￥100,000

7. “乳腺癌、头颈癌及脑部检测的漫射光血流技术方案”

   浙江长兴维力华能源科技有限公司 横向项目  2018/1/10/-2020/1/10

   经费：￥877,700

8. “乳腺癌早期筛查的漫射光血流成像系统组建、校准和评测技术方案”

   香港伟胜科技发展有限公司 横向项目   2022/1/5/-2022/12/31

   经费：￥517,000

9. “血液动力学成像系统和人工智能影像分析的乳腺肿瘤检测”

   国家重点研发计划（科技部）2023YFE0202800    2023/7/1-2025/6/30

   经费：￥4,450,000

（四）授权专利

1. 中国发明专利：ZL201810974797.X

   题目：人脑微血管系统血流的仿体试验台；授权公告日：2020年4月24日

2. 中国发明专利：ZL201811584435.X

   题目：利用单距离光源-探测器对测量组织饱和度的方法； 授权公告日：2021年7月16日

3. 中国发明专利：ZL201810447228.3

   题目：一种基于NSST和CNN的数字图像降噪方法； 授权日期：2021年9月21日

 六、获奖、荣誉称号

1. 2023年作为指导老师获得全国大学生生物医学电子创新设计竞赛一等奖

2. 2022年被评为中北大学2022年“师德标兵”荣誉称号

3. 2022年作为指导教师获得第十七届“挑战杯”全国大学生课外学术科技竞赛三等奖

4. 2021年作为指导教师获得第十六届中国研究生电子设计竞赛全国总决赛二等奖

5. 2021年作为指导教师获得第七届山西省“互联网+”大学生创新创业大赛金奖

6. 2020年作为硕士生导师获得山西省优秀学位论文（两篇）

7. 2020年作为指导老师获得第六届中国国际“互联网+”大学生创新创业大赛全国铜奖

8. 2019年入选 “中共山西省委联系服务的高级专家”

9. 2019年作为指导教师获得第五届山西省“互联网+”大学生创新创业大赛金奖

10. 2019年作为指导教师获得第十六届“挑战杯”全国大学生课外学术科技竞赛三等奖

11. 2019年作为指导教师获得第十四届中国研究生电子设计竞赛全国总决赛二等奖

12. 2018年作为指导老师获得全国大学生生物医学电子创新设计竞赛二等奖

13. 2017年入选山西省引进海外高层次“百人计划”；聘任 “山西特聘专家”

14. 2015年入选西安交通大学“青年拔尖人才支持计划”（特聘研究员）

15. 2015年入选马奎斯美国名人录（Marquis Who's Who in America）

16. 当选2012年度Journal of Biomedical Optics  “十佳审稿人(Top 10 reviewers)”

17. 2011年获得国际会议ECI (Engineering Conferences International)旅行奖金

18. 2005年获得全国研究生数学建模竞赛二等奖

19. 2003作为指导教师获得高教社杯全国大学生数学建模竞赛，获得全国一等奖、全国二等奖各一项