• 师资力量
    王梅梅
    发布时间:2023-05-31


    学       历:博士研究生

    职       称:讲师

    电子邮箱:mmwang@dgut.edu.cn

    研究领域:1.天然活性成分药理机制研究

                      2.代谢稳态及其在慢性炎症的调控机制

                               

    一、教育、工作经历:

    20233月 至今,东莞理工学院生命健康技术学院,讲师

    20189月 - 202212月,华南理工大学医学院,博士

    20159月 20186月,西南大学药学院,硕士

    20119月 20156月,河南中医药大学药学院,学士

    二、研究领域

    天然活性成分药理机制研究:聚焦中药及药食同源天然活性成分,依托多组学、细胞分子生物学等技术,探究其在神经免疫调节、慢性炎症发生发展中的作用靶点与分子机制,推动天然产物及功能性资源的现代化研究与应用开发。

    代谢稳态及其在慢性炎症的调控机制研究:研究机体代谢稳态维持的分子基础,解析代谢紊乱与神经炎症发生发展的内在关联及调控网络;探究代谢失衡介导慢性低度炎症的关键信号通路,同时挖掘天然活性成分调控代谢稳态、抑制慢性炎症的作用机制,为代谢性炎症相关疾病的干预提供理论依据。

    三、主要业绩:

    主持或参与国家自然科学基金面上及重点等多项项目的研究;主持或参与多项教改项目;在国内外SCI期刊发表学术论文10余篇,其中以第一作者(共同第一作者)发表高水平SCI论文6篇,包括Nature Communication (中科院1区,IF15.7)、Acta Biomaterialia (中科院1区,IF10.5)、Cell Death & Disease (中科院1区,IF12.2)

    四、 代表性研究成果

    1.  Xie Biao, Wang Meimei, Xiao Yaping, Zhang Xin, Liu Meng, Miao Jie, Mo Yunfei, Liu Hongxin, Wang Jihui, Xu Fengguo, Wang Di. Tryptophan metabolic gatekeeping in epithelial repair: GPR35-KLF5 circuitry decodes mucosal damage signals for repair programming. Cell Death Dis. 2026 Jan 9;17(1):25.1区)

    2.  Sun W, Wang Meimei, Zhao J, Zhao S, Zhu W, Wu X, Li F, Liu W, Wang Z, Gao M, Zhang Y, Xu J, Zhang M, Wang Q, Wen Z, Shen J, Zhang W, Huang Z. Sulindac selectively induces autophagic apoptosis of GABAergic neurons and alters motor behaviour in zebrafish. Nat Commun. 2023 Sep 2;14(1):5351.1区)

    3.  Wang Meimei, Xiao Yaping, Miao Jie, Zhang Xin, Liu Meng, Zhu Longchao, Liu Hongxin, Shen Xiaoyan, Wang Jihui, Xie Biao, Wang Di. Oxidative Stress and Inflammation: Drivers of Tumorigenesis and Therapeutic Opportunities. Antioxidants. 2025 Jun 15;14(6):735. (2)

    4.  Wang Meimei, Yang Zhenyu, Song Yang, et al. Proteasomal and autophagy-mediated degradation of mutp53 proteins through mitochondria-targeting aggregation-induced-emission materials[J]. Acta Biomaterialia, 2022, 150: 402-412.1区)

    5.  Wang Meimei, Ma Hang, Li Zhaoxing, et al. SPG-56 from Sweet potato Zhongshu-1 delayed growth of tumor xenografts in nude mice by modulating gut microbiota[J]. Journal of Functional Foods, 2019, 52: 291-301.1区)

    6.  Wang Meimei, Ma Hang, Tian Cheng, et al. Bioassay-guided isolation of glycoprotein SPG-56 from sweet potato Zhongshu-1 and its anti-colon cancer activity in vitro and in vivo[J]. Journal of Functional Foods, 2017, 35: 315-324.1区)

    7.  Tian Cheng, Wang Meimei, Liu Shanshan, et al. A new glycoprotein SPG-8700 isolated from sweet potato with potential anti-cancer activity against colon cancer[J]. Natural product research, 2019, 33(16): 2322-2328.3区)

    8.  Jing Manman, Li Yafei, Wang Meimei, et al. Photoresponsive PAMAM‐Assembled Nanocarrier Loaded with Autophagy Inhibitor for Synergistic Cancer Therapy[J]. Small, 2021, 17(38): 2102295.1区)

    9. . Ishimwe Nestor, Wei Pengfei, Wang Meimei, et al. Autophagy impairment through lysosome dysfunction by brucine induces immunogenic cell death (ICD)[J]. The American Journal of Chinese Medicine, 2020, 48(08): 1915-1940.

    10.  Ma Hang, Yu Yang, Wang Meimei, et al. Correlation between microbes and colorectal cancer: tumor apoptosis is induced by sitosterols through promoting gut microbiota to produce short-chain fatty acids[J]. Apoptosis, 2019, 24(1): 168-183.

    11.  Li Zhaoxing, Yu Yang, Wang Meimei, et al. Anti-breast cancer activity of SPG-56 from sweet potato in MCF-7 bearing mice in situ through promoting apoptosis and inhibiting metastasis[J]. Scientific reports, 2019, 9(1): 1-12.


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